|
T6777 |
Bay K 8644
|
(±)-BAY-K-8644,SQ 28,873 |
Calcium Channel
|
|
Bay K 8644 (SQ 28,873) is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM. |
|
T0370 |
Pheniramine maleate
|
Daneral,Inhiston,Trimetose |
5-HT Receptor
,
Histamine Receptor
|
|
Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re... |
|
T11480 |
GSK205
|
|
Others
|
|
GSK205 is a selective TRPV4 antagonist (IC50: 4.19 μM) for inhibiting TRPV4-mediated Ca2+ influx. |
|
T12234 |
NMDA-IN-1
|
|
NMDAR
|
|
NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM). |
|
TNU0864 |
HUP30
|
|
Potassium Channel
,
Calcium Channel
|
|
HUP30 is a potent vasodilating agent. HUP30 can stimulate soluble guanylyl cyclase, activate K+ channels, and block extracellular Ca2+ influx. |
|
T11102 |
DS16570511
|
|
Calcium Channel
|
|
DS16570511 is a novel, cell-permeable inhibitor targeting the mitochondrial calcium uniporter. It effectively blocks the increase in Ca2+ influx dependent on MCU or MICU1 [1]. |
|
T16687 |
Pyr3
|
|
TRP/TRPV Channel
|
|
Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM). |
|
T16688 |
Pyr6
|
N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide |
TRP/TRPV Channel
|
|
Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide) is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 ... |
|
T16686 |
Pyr10
|
|
TRP/TRPV Channel
|
|
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits... |
|
T10782 |
CGP52411
|
DAPH |
EGFR
,
Beta Amyloid
|
|
CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramatically inhibits and reverses the formation of β-amyloid Aβ42... |
|
TP1910L1 |
CALP1 acetate
|
CALP1 acetate(145224-99-3 free base) |
CaMK
|
|
CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) by inhibiting the open of calcium channel. CALP1 blo... |
|
T2711 |
Chembridge-5861528
|
TCS 5861528 |
TRP/TRPV Channel
|
|
Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively. |
|
T6530 |
HC-030031
|
HC030031,TOSLAB 829227 |
TRP/TRPV Channel
|
|
HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively. |
|
T5148 |
Atosiban acetate
|
RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164 |
Oxytocin Receptor
,
Vasopressin Receptor
|
|
Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban acetate (RW22164) inhibits... |
|
T27639 |
ITH-12575
|
|
|
|
ITH-12575 is an inhibitor of Mitochondrial Na+/Ca2+ exchange (mNCX). ITH12575 reduces Ca(2+) influx through CALHM1 at low micromolar concentrations. |
|
T68361 |
Asocainol hydrochloride
|
|
|
|
Asocainol hydrochloride ia an antiarrhythmic drug which inhibits slow Ca2+ influx. This is accompanied by alterations in normal Na+-carried action potentials. Therefore, Asocainol not only inhibits Ca2+ inflow but also i... |
|
T14829 |
Bromoenol lactone
|
(6E)-Bromoenol lactone |
Phospholipase
|
|
Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ infl... |
|
T80441 |
FS-2
|
|
Calcium Channel
|
|
FS-2 is a potent, specific inhibitor of L-type CaV channels, effectively impeding high K+ or glucose-induced L-type Ca2+ influx in RIN beta cells [1]. |
|
T37475 |
Cyclic ADP-Ribose (ammonium salt)
|
cADP-Ribose,cADPR,Cyclic ADP-Ribose (ammonium salt) |
|
|
Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second mes... |
|
T40101 |
(±)-1,2-Diolein
|
1,2-Dioleoyl-rac-glycerol |
PKC
|
|
(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx. |
|
T26452 |
A 80b
|
A80b,A-80b |
|
|
A-80b is a synthesized pyridazino[4,5-b]indole derivate with potent and long-lasting antihypertensive activity. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency ... |
|
TP1910 |
CALP1
|
|
|
|
Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-... |
|
T76203 |
Syringomycin E
|
|
|
|
Syringomycin E, an antifungal cyclic lipodepsinonapeptide, inhibits the growth of Saccharomyces cerevisiae by interacting with the plasma membrane. It induces K+ efflux, Ca2+ influx, and alterations in membrane potential... |
|
T23102 |
OBAA
|
|
Others
|
|
OBAA is a potent inhibitor of phospholipase A2 (PLA2) with an IC 50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC 50 of 0.4 μM [1] [2] [3]. |
|
T75793 |
ω-Agatoxin IVA TFA
|
|
|
|
ω-Agatoxin IVA TFA is a potent selective inhibitor of P/Q type Ca2+ (Cav2.1) channels, exhibiting IC50 values of 2 nM for P-type and 90 nM for Q-type channels. It effectively inhibits glutamate exocytosis and calcium inf... |
|
T75791 |
CALP1 TFA
|
|
|
|
CALP1 TFA, a calmodulin (CaM) agonist with a dissociation constant (Kd) of 88 µM, selectively binds to the CaM EF-hand/Ca2+-binding site, inhibiting calcium channel opening. This action blocks calcium influx and apoptosi... |
|
T80930 |
TRPV2-selective blocker 1
|
|
|
|
TRPV2-selective blocker 1 (compound IV2-1) is a selective inhibitor of the TRPV2 channel, exhibiting an IC50 value of 6.3 μM. It specifically targets the TRPV2 channel without impacting related TRPV1, TRPV3, or TRPV4 cha... |
|
T4996 |
Atosiban
|
RWJ22164,RW22164 |
Oxytocin Receptor
,
Vasopressin Receptor
|
|
Atosiban (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated rel... |
|
T73453 |
MRS4719
|
|
|
|
MRS4719, a potent P2X4 receptor antagonist, exhibits a half-maximal inhibitory concentration (IC50) of 0.503 μM for the human P2X4 receptor. Demonstrating both neuroprotective and neuro-rehabilitative effects, it can dec... |
|
T36805 |
TPC2-A1-N
|
TPC2-A1-N |
|
|
TPC2-A1-N is a novel, lipophilic, membrane permeable isoform-selective small molecule agonist of two-pore channel 2 (TPC2). TPC2-A1-N plays its role by mimicking the physiological actions of NAADP and PI(3,5)P2 through i... |
